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VASO Trial (Vitamin D and Arthroplasty Surgery Outcomes)

VASO Trial (Vitamin D and Arthroplasty Surgery Outcomes)

Posted on: 29-11-2017

Low vitamin D levels (insufficiency) are common in the UK population, mainly due to inadequate sun exposure. Studies have suggested there may be a link between vitamin D insufficiency and poor outcomes after surgery, but that more research is needed. The VASO trial is being carried out to investigate if giving vitamin D supplements to patients with a low vitamin D level before their hip or knee replacement makes a difference to the outcome following surgery. Our researchers are measuring the Vitamin D level of 100 patients undergoing hip or knee replacement at two hospitals in the North East of England. Those patients who have a low vitamin D level are randomised to one of two groups: either to receive treatment with vitamin D supplements before their operation and for six months afterwards, or to receive no supplements. Randomisation means that a computer randomly chooses which of the two groups the patient ends up in, which is equivalent to tossing a coin. No other aspects of surgery or recovery will be changed.

All patients having a hip or knee replacement in the NHS routinely complete questionnaires before their operation and at six months afterwards, to help assess if surgery has made a difference to their function. We will use the responses to these questionnaires to help us see if giving vitamin D supplements makes a difference in the outcome. The researchers will also look at other factors such as how long patients stay in the hospital for after surgery, if they need to be readmitted to hospital, if they have a wound infection or if they have any other complications.

This initial small-scale trial, called a ‘feasibility trial’, only includes 100 patients, but allows scientists to see if it would be possible to perform a bigger trial involving more patients across the rest of the country, as well as informing them if any parts of the trial need to be altered.

https://www.ncbi.nlm.nih.gov/pubmed/29096686

Researchers: Rory Morrison (pictured above), Deborah Bunn, Keith Gray, Paul Baker, Craig White, Amar Rangan, Kenny Rankin and Mike Reed

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